A Potential Outcomes Approach to Developmental Toxicity Analyses
نویسندگان
چکیده
منابع مشابه
A potential outcomes approach to developmental toxicity analyses.
Estimating the effects of a toxin on fetal development in animal models such as mice can be problematic, because the number of pups that develop and survive until birth may simultaneously affect developmental outcomes such as birth weight and be affected by the introduction of a toxin into the fetal environment. Also, comparing pups that survived until birth at a high dose of the toxin with pup...
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A novel approach to generate robust classification models to predict developmental toxicity from imbalanced datasets.
Computational models to predict the developmental toxicity of compounds are built on imbalanced datasets wherein the toxicants outnumber the non-toxicants. Consequently, the results are biased towards the majority class (toxicants). To overcome this problem and to obtain sensitive but also accurate classifiers, we followed an integrated approach wherein (i) Synthetic Minority Over Sampling (SMO...
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ژورنال
عنوان ژورنال: Biometrics
سال: 2006
ISSN: 0006-341X
DOI: 10.1111/j.1541-0420.2005.00506.x